The description "🤷‍♂️🙅‍♀️💁‍♂️" represents a combination of three emojis: a man shrugging, a woman gesturing "no," and a man gesturing "ok." It conveys a sense of uncertainty, disagreement, and nonchalance. When related to the phrase "I don't give a," it could imply a lack of interest or concern about a particular matter.